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Phytol, a diterpene alcohol, is a constituent of chlorophyll and serves as a precursor for the synthesis of vitamins E and K1. Within the context of cannabis, phytol is noteworthy due to its presence as a naturally occurring terpene in the plant’s trichomes, where it contributes to the complex aroma and potential therapeutic effects of cannabis. The structure of phytol consists of a long hydrocarbon chain with an alcohol functional group, which renders it moderately hydrophobic and thus able to integrate into lipid-based structures. This terpene exhibits a range of biological activities that may synergize with other compounds in cannabis, including anti-inflammatory, anxiolytic, and anti-nociceptive properties. In cannabis research, the exploration of phytol’s role is not merely confined to its sensory impact but extends to its potential modulation of the endocannabinoid system and its influence on the pharmacokinetics and pharmacodynamics of cannabinoids. Consequently, phytol and its derivatives are subjects of interest for their potential to enhance the therapeutic profile of cannabis-based treatments.

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