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Humulene, also known as α-humulene or alpha-humulene, is a naturally occurring monocyclic sesquiterpene that is a vital constituent in the essential oil of Cannabis sativa, among other plants. It is characterized by a unique cyclic structure consisting of three isoprene units, which contributes to its distinctive molecular formula, C15H24. Humulene imparts a subtle earthy, woody aroma that is often associated with hops, from which its name is derived. In the context of cannabis, humulene not only contributes to the plant’s aromatic profile but has also been the subject of scientific interest due to its potential therapeutic properties. Research has suggested that humulene may possess anti-inflammatory and analgesic effects, which could play a role in the medicinal qualities attributed to certain strains of cannabis. Furthermore, the presence of humulene and other terpenes is believed to contribute to the entourage effect, a synergistic interaction that potentially enhances the pharmacological efficacy of cannabinoids. As such, humulene is not only a defining feature of cannabis’ olfactory signature but also a compound of interest in the ongoing exploration of the plant’s full therapeutic potential.

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