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Beta-caryophyllene, also known as BCP, is a sesquiterpene uniquely present in the essential oils of various plants, including cannabis, black pepper, and oregano. It is renowned for its ability to interact with the endocannabinoid system’s CB2 receptors, which play a crucial role in regulating inflammation and the immune system. This interaction is particularly notable as it makes beta-caryophyllene the only terpene known to bind selectively to these receptors, without eliciting psychoactive effects.

Chemically distinguished by its bicyclic structure, which includes a rare cyclobutane ring fused to a cyclohexene ring, beta-caryophyllene imparts a characteristic spicy, peppery aroma to certain cannabis strains and other spice plants. This complex molecular geometry contributes not only to its distinctive scent profile but also to its significant role in the pharmacological properties of cannabis-based products.

In terms of health benefits, beta-caryophyllene exhibits promising anti-inflammatory and analgesic (pain-relieving) properties. It has shown potential in managing inflammatory conditions and may also reduce anxiety and depression by modulating the endocannabinoid system. Its unique ability to bind to CB2 receptors, implicated in various physiological processes related to inflammation and pain, makes it a compound of interest for therapeutic applications.

Beta-caryophyllene’s presence in cannabis contributes to more than just the plant’s aromatic profile; it also influences the plant’s effects on the human body, playing a key role in the entourage effect where it synergizes with cannabinoids and other terpenes to potentially enhance the therapeutic impact of cannabis.


Beta-Caryophyllene Terpene Chart

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