Neuroprotectants are a class of compounds that have the potential to preserve the structure and function of neural tissue. They are designed to intervene in the pathological processes that lead to neuronal injury or death. The primary aim of neuroprotectants is to prevent or slow the progression of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, as well as to mitigate the effects of acute events like stroke and traumatic brain injury. The mechanisms by which neuroprotectants exert their effects are diverse and can include the inhibition of excitotoxicity, which is the damaging overactivation of neurons by neurotransmitters such as glutamate; reduction of oxidative stress by scavenging free radicals; modulation of neuroinflammation; stabilization of mitochondrial function; and regulation of apoptotic pathways that lead to cell death. The therapeutic efficacy of neuroprotectants is an area of intense research, with numerous preclinical studies and clinical trials being conducted to evaluate their potential benefits. The development of effective neuroprotectants could have a significant impact on the treatment of neurological disorders and the improvement of outcomes for patients suffering from these conditions.
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