Cannabinoid receptor type 2, commonly abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that is found in the human body. It is one of the two primary cannabinoid receptors, with the other being cannabinoid receptor type 1 (CB1). While CB1 receptors are primarily located in the central nervous system, CB2 receptors are mainly found in the peripheral nervous system, particularly in immune cells. CB2 plays a significant role in the modulation of immune system responses and inflammation. The activation of CB2 receptors has been shown to have anti-inflammatory effects, which can be beneficial for treating various medical conditions such as pain, autoimmune diseases, and neurodegenerative disorders. The discovery and understanding of CB2 have led to significant research into the therapeutic potential of targeting this receptor with cannabinoids, which are the active compounds found in the cannabis plant. This has implications for the development of new drugs that can selectively activate CB2 receptors to achieve desired therapeutic outcomes without the psychoactive effects typically associated with CB1 receptor activation.