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An analgesic, commonly known as a painkiller, is a type of medication used to achieve analgesia, which is relief from pain. The term stems from the Greek words “an” meaning “without” and “algos” meaning “pain”. Analgesics work by blocking pain signals from traveling along the nerves to the brain or by altering the brain’s interpretation of those signals. There are various classes of analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen (paracetamol), and opioids. NSAIDs, such as ibuprofen and aspirin, not only reduce pain but also diminish inflammation, making them particularly useful for conditions like arthritis. Acetaminophen is effective for mild to moderate pain and is often recommended for its fewer side effects and lower risk of causing stomach ulcers compared to NSAIDs. Opioids, such as morphine and codeine, are used for more severe pain and work by binding to opioid receptors in the brain, spinal cord, and other areas of the body, reducing the perception of pain. However, they carry a significant risk of addiction and other serious side effects. The choice of analgesic and the administration route—oral, topical, transdermal, or intravenous—depend on the type, duration, and severity of pain, as well as patient-specific factors. Proper management and prescription of analgesics are crucial to minimize potential risks and ensure effective pain control.

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